SARS-CoV-2 (COVID-19) 3CL-Mpro Protein, Tag-free

Cysteine protease 3CL-Mpro of SARS-CoV-2 (COVID-19) that cleaves the transcribed viral polyprotein into several functional proteins at two self-cleavage sites.

Overview

Product NameSARS-CoV-2 (COVID-19) 3CL-Mpro Protein, tag-free
Catalog No.P2020-019
RefSeq LinksNC_045512.2; MN908947.3; YP_009724390.1; QHD43416.1; GeneID: 43740568
Synonyms3CL Mpro; 3CL protease; 3C-like main protease; SARS-CoV-2; coronavirus; 2019-nCoV; COVID-2019; COVID-19

Sequence Information

SpeciesSARS-CoV-2; Wuhan seafood market pneumonia virus
Tagstag-free
Sequence without tagsSGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIR
KSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNG
SPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGN
FYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQC
SGVTFQ

Product Information

Expression HostE. coli
FormulationPBS, pH 7.4; contains Glycerol as protectant
FormatLiquid, stored and shipped at -80°C
Purity> 90% as determined by SDS-PAGE

Background Information

 

The new coronavirus SARS-CoV-2 expresses two proteases, the papain-like protease (PLpro) and 3C-like protease (3CLpro). Both belong to the group of cysteine proteases, as they have a cysteine residue at their catalytic site. Their main function is the processing of the viral polyprotein, that contains two cleavage sites to build up the viral replicase complex. Additionally, PLpro has the ability of removing ISG15 and ubiquitin from viral proteins expressed in the cell, this enables evasion from the innate immune response by the host. This presents an interesting target for drug development, as it would not only inhibit the viral replication but would also prevent the massive immunological response resulting of the over-activation of the host´s immune system, that can lead to damaging of uninfected cells and therefore worsening of the patient´s condition.

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Reinhold Horlacher, PhD

Reinhold Horlacher, PhD

Managing Director & CSO

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