SARS-CoV-2 (2019-nCoV) Spike S1 Protein (RBD)
Recombinant protein of the receptor binding domain (RBD) of SARS-CoV-2 (2019-nCoV) Spike S1 from Wuhan pneumonia virus with C-terminal His-Tag.
|Product Name||SARS-CoV-2 (2019-nCoV) Spike S1 Protein (RBD)|
|RefSeq Links||NC_045512.2 ; MN908947.3; YP_009724390.1 ; QHD43416.1 ; GeneID: 43740568|
|Synonyms||SARS-CoV-2; coronavirus; SARS-CoV-2 spike RBD; SARS-CoV-2 spike protein; 2019-nCoV; COVID-2019; COVID-19|
|Species||Wuhan seafood market pneumonia virus; 2019-nCoV|
|Sequence without tags||RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYA
|Expression Host||human, HEK293|
|Formulation||PBS, pH 7,4|
|Format||Liquid, stored and shipped at -80°C|
|Purity||> 90% as determined by SDS-PAGE|
|The spike (S) glycoprotein of coronaviruses is essential for binding of the virus to the host cell at the beginning of the infection process. The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein is responsible for membrane fusion and is therefore required for virus entry and cell fusion. The target protein is also a major immunogen and a possible target for entry inhibitors.
The SARS-CoV-2 spike (S) protein is a large type I transmembrane protein composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain (RCB) responsible for binding to the host cell receptor angiotensin-converting enzyme 2 (ACE2). The S2 subunit mediates fusion between the viral and host cell membranes. The S1 RBD protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Reinhold Horlacher, PhD
Managing Director & CSO
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